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Perptm1Att
Targeted Allele Detail
Summary
Symbol: Perptm1Att
Name: PERP, TP53 apoptosis effector; targeted mutation 1, Laura D Attardi
MGI ID: MGI:2683069
Synonyms: Perp-
Gene: Perp  Location: Chr10:18720819-18732821 bp, + strand  Genetic Position: Chr10, 7.97 cM, cytoband A2
Alliance: Perptm1Att page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86549
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment encompassing exons 2 and 3 were replaced with a single loxP site after cre mediated recombination of a single loxP site in intron 3 and the 5' loxP site of a floxed puromycin cassette in intron 1. Neither normal or truncated transcript was detected by Northern blot analysis of homozygous mutant ES cells treated with a DNA damaging agent. (J:86549)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 20 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Perptm1Att
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Perp Mutation:  9 strains or lines available
References
Original:  J:86549 Ihrie RA, et al., Perp is a mediator of p53-dependent apoptosis in diverse cell types. Curr Biol. 2003 Nov 11;13(22):1985-90
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory