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Transgene Detail
Symbol: Tg(PLADA)4118Rkmb
Name: transgene insertion 4118, Michael R Blackburn
MGI ID: MGI:2683027
Transgene: Tg(PLADA)4118Rkmb  Location: unknown  
Lung, bone and kidney abnormalities are observed in Adatm1Mw/Adatm1Mw Tg(PLADA)4118Rkmb/0 mice

Show the 2 phenotype image(s) involving this allele.

Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(PLADA)4118Rkmb expresses 1 gene
Mutation detailsA construct was made that contained the endogenous polyadenylation sequence, intron 11, and ~2kb of of the 3' flanking region of the gene. The endogenous promoter was replaced with a promoter containing a 36-bp deletion in the 5'-untranslated region and 770-bp trophoblast regulatory element. This resulted in a construct that allowed expression in the placenta prenatally only, while the 36-bp deletion in the promoter allowed distinction of this transcript from that of native transcript. Enzymatic activity of the protein product was not detected in any of the tissues tested at postnatal day 17 in transgenic mice. (J:73418)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 9 anatomical structures
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:73418 Blackburn MR, et al., Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency. J Biol Chem. 1998 Feb 27;273(9):5093-100
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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