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Hbegftm3Mek
Targeted Allele Detail
Nomenclature
Symbol: Hbegftm3Mek
Name: heparin-binding EGF-like growth factor; targeted mutation 3, Eisuke Mekada
MGI ID: MGI:2682961
Synonyms: HBdelta-tm
Gene: Hbegf  Location: Chr18:36504929-36515805 bp, - strand  Genetic Position: Chr18, 19.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86547
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA stop codon was introduced in the cDNA sequence between the codons for amino acid residue 148 and 149. The modified cDNA sequence was then fused to the start codon of exon 1 along with IRES, a neomycin resistance gene and a polyadenylation sequence. RT-PCR of skin and heart specimens confirmed the presence of the modified mRNA transcript. The predicted soluble protein product was detected immunologically. (J:86547)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hbegf Mutation:  15 strains or lines available
References
Original:  J:86547 Yamazaki S, et al., Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities. J Cell Biol. 2003 Nov 10;163(3):469-75
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory