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Targeted Allele Detail
Symbol: Trpv4tm1Rck
Name: transient receptor potential cation channel, subfamily V, member 4; targeted mutation 1, J M Friedman
MGI ID: MGI:2682656
Synonyms: trpv4-
Gene: Trpv4  Location: Chr5:114622152-114658421 bp, - strand  Genetic Position: Chr5, 55.99 cM, cytoband F
Trpv4tm1Rck/Trpv4tm1Rck mice show protection from UVB-induced skin injury

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:86560
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA single loxP site was left in place of exon 12 after cre mediated recombination of a single loxP site in intron 11 and a floxed neo cassette in intron 12. Protein was undetected by Western blot analysis of homozygous mutant kidney extracts. (J:86560)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpv4 Mutation:  30 strains or lines available
Original:  J:86560 Liedtke W, et al., Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13698-703
All:  39 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory