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Ets2tm2Rgo
Targeted Allele Detail
Nomenclature
Symbol: Ets2tm2Rgo
Name: E26 avian leukemia oncogene 2, 3' domain; targeted mutation 2, Robert G Oshima
MGI ID: MGI:2682649
Synonyms: Ets2tm1Osh, Ets2tmA72Osh, EtsA72
Gene: Ets2  Location: Chr16:95503274-95522093 bp, + strand  Genetic Position: Chr16, 56.64 cM, cytoband C3-qter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86530
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsThe ACT codon for threonine at amino acid residue 72 was changed to a GCT alanine codon. At the same time, the CCC codon for amino acid residue 73 was changed to CCA which eliminated a Pst 1 restriction site but did not have any other effect. Finally, a floxed neomycin gene was inserted in intron 4. The neomycin resistance gene was removed in vivo by mating to mice expressing Cre recombinase from the protamine promoter in the male germ line. Production and turnover of the modified protein were similar to unmodified protein. (J:86530)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ets2 Mutation:  28 strains or lines available
References
Original:  J:86530 Man AK, et al., Ets2-dependent stromal regulation of mouse mammary tumors. Mol Cell Biol. 2003 Dec;23(23):8614-25
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory