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Slc4a7tm1Krtz
Targeted Allele Detail
Nomenclature
Symbol: Slc4a7tm1Krtz
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7; targeted mutation 1, Ira Kurtz
MGI ID: MGI:2682641
Synonyms: Slc4a7-
Gene: Slc4a7  Location: Chr14:14703011-14799944 bp, + strand  Genetic Position: Chr14, 7.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86635
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 3' portion of exon 5 was replaced with a MC1-neo cassette. Protein was undetected by Western blot analysis of homozygous mutant mice using a C-terminal antibody. (J:86635)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc4a7 Mutation:  47 strains or lines available
References
Original:  J:86635 Bok D, et al., Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3. Nat Genet. 2003 Jul;34(3):313-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory