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Slc6a9tm1Betz
Targeted Allele Detail
Nomenclature
Symbol: Slc6a9tm1Betz
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 9; targeted mutation 1, Heinrich Betz
MGI ID: MGI:2682493
Synonyms: GlyT1-/-
Gene: Slc6a9  Location: Chr4:117834506-117875198 bp, + strand  Genetic Position: Chr4, 53.62 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86624
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was replaced with a neo cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of RNA obtained from homozygous mutant brain stem and spinal cord tissue. Similarly, Western blot analysis indicated an absence of protein in extracts from homozygous mutant brain stem and spinal cord tissue. (J:86624)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a9 Mutation:  1 strain or line available
References
Original:  J:86624 Gomeza J, et al., Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition. Neuron. 2003 Nov 13;40(4):785-96
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory