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Targeted Allele Detail
Symbol: Slc6a9tm1Betz
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 9; targeted mutation 1, Heinrich Betz
MGI ID: MGI:2682493
Synonyms: GlyT1-/-
Gene: Slc6a9  Location: Chr4:117834506-117875198 bp, + strand  Genetic Position: Chr4, 53.62 cM
Germline Transmission:  Earliest citation of germline transmission: J:86624
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3 was replaced with a neo cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of RNA obtained from homozygous mutant brain stem and spinal cord tissue. Similarly, Western blot analysis indicated an absence of protein in extracts from homozygous mutant brain stem and spinal cord tissue. (J:86624)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a9 Mutation:  11 strains or lines available
Original:  J:86624 Gomeza J, et al., Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition. Neuron. 2003 Nov 13;40(4):785-96
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory