Krt2^Mhdadsk2
Chemically induced Allele Detail

Summary

• Symbol: Krt2^Mhdadsk2
• Name: keratin 2; Martin Hrabe de Angelis dark skin 2
• MGI ID: MGI:2682236
• Synonyms: Krt2^Dsk2
• Gene: Krt2 Location: Chr15:101719124-101726604 bp, - strand Genetic Position: Chr15, 57.03 cM
• Alliance: Krt2^Mhdadsk2 page

Mutation origin

• Strain of Origin: C3HeB/J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation was identified as an A to C transversion causing a missense mutation that predicts a Thr5000Pro substitution in the rod 2b domain, a domain known to be important for keratin keratin interactions. (J:81301)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt2 Mutation: 47 strains or lines available

References

• Original: J:81301 Fitch KR, et al., Genetics of dark skin in mice. Genes Dev. 2003 Jan 15;17(2):214-28
• All: 1 reference(s)