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Targeted Allele Detail
Symbol: Ext1tm1Yama
Name: exostoses (multiple) 1; targeted mutation 1, Yu Yamaguchi
MGI ID: MGI:2682061
Synonyms: Ext1f, Ext1flox
Gene: Ext1  Location: Chr15:53064038-53346159 bp, - strand  Genetic Position: Chr15, 20.0 cM
Craniofacial malformation in Ext1tm1Yama/Ext1tm1YamaTg(Wnt1-cre)11Rth/0 mice

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:86465
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe coding region of exon 1 was flanked by single loxP sites in the 5' untranslated region of exon 1 and in intron 1. The targeting vector contained a frt-flanked neomycin cassette in intron 1, though this selection cassette was removed via in vivo FLP-mediated recombination. (J:86465)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ext1 Mutation:  33 strains or lines available
Original:  J:86465 Inatani M, et al., Mammalian brain morphogenesis and midline axon guidance require heparan sulfate. Science. 2003 Nov 7;302(5647):1044-6
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory