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Ubr2tm1Ytkw
Targeted Allele Detail
Nomenclature
Symbol: Ubr2tm1Ytkw
Name: ubiquitin protein ligase E3 component n-recognin 2; targeted mutation 1, Yong Tae Kwon
MGI ID: MGI:2682037
Synonyms: UBR2-
Gene: Ubr2  Location: Chr17:46928292-47010532 bp, - strand  Genetic Position: Chr17, 22.91 cM
Abnormal development of the central nervous system in Ubr1tm1Avar/Ubr1tm1Avar Ubr2tm1Ytkw/Ubr2tm1Ytkw embryos

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86438
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsDNA from codon 7 (Cys) of exon 3 through codon 16 (His) of exon 6 was replaced in frame with the nuclear localization signal(NLS)-lacZ marker gene. No beta-galactosidase activity was observed however. Low levels of gene transcript could be detected by Northern blot. (J:86438)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ubr2 Mutation:  43 strains or lines available
References
Original:  J:86438 Kwon YT, et al., Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. Mol Cell Biol. 2003 Nov;23(22):8255-71
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory