Tas1r3^tm1Csz
Targeted Allele Detail

Summary

• Symbol: Tas1r3^tm1Csz
• Name: taste receptor, type 1, member 3; targeted mutation 1, Charles S Zuker
• MGI ID: MGI:2681887
• Synonyms: T1R3^-
• Gene: Tas1r3 Location: Chr4:155943725-155947810 bp, - strand Genetic Position: Chr4, 87.65 cM
• Alliance: Tas1r3^tm1Csz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86474
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 5 were replaced with a PGK-neo cassette inserted by homologous recombination. The deleted sequence encoded the N-terminal extracellular domain. Protein was undetected by in situ hybridization of homozygous mutant taste bud sections. (J:86474)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tas1r3 Mutation: 36 strains or lines available

References

• Original: J:86474 Zhao GQ, et al., The receptors for mammalian sweet and umami taste. Cell. 2003 Oct 31;115(3):255-66
• All: 24 reference(s)