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Targeted Allele Detail
Symbol: Tas1r3tm1Csz
Name: taste receptor, type 1, member 3; targeted mutation 1, Charles S Zuker
MGI ID: MGI:2681887
Synonyms: T1R3-
Gene: Tas1r3  Location: Chr4:155943725-155947810 bp, - strand  Genetic Position: Chr4, 87.65 cM
Germline Transmission:  Earliest citation of germline transmission: J:86474
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 through 5 were replaced with a PGK-neo cassette inserted by homologous recombination. The deleted sequence encoded the N-terminal extracellular domain. Protein was undetected by in situ hybridization of homozygous mutant taste bud sections. (J:86474)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tas1r3 Mutation:  23 strains or lines available
Original:  J:86474 Zhao GQ, et al., The receptors for mammalian sweet and umami taste. Cell. 2003 Oct 31;115(3):255-66
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory