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Fbln5tm1Krc
Targeted Allele Detail
Nomenclature
Symbol: Fbln5tm1Krc
Name: fibulin 5; targeted mutation 1, Kenneth R Chien
MGI ID: MGI:2681527
Synonyms: fibulin-5-
Gene: Fbln5  Location: Chr12:101746565-101819055 bp, - strand  Genetic Position: Chr12, 51.29 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86753
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a cassette containing lacZ and neo replaced the first 4 exons of the endogenous gene. Transcript was undetected in homozygous mutant mice by Northern blot analysis and in situ hybridization of the pulmonary artery and lungs. (J:86753)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbln5 Mutation:  11 strains or lines available
References
Original:  J:86753 Nakamura T, et al., Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. 2002 Jan 10;415(6868):171-5
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory