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Targeted Allele Detail
Symbol: Fbln5tm1Eno
Name: fibulin 5; targeted mutation 1, Eric N Olson
MGI ID: MGI:2681517
Synonyms: C18-6, fbln5-, fibulin-5-
Gene: Fbln5  Location: Chr12:101746565-101819055 bp, - strand  Genetic Position: Chr12, 51.29 cM, cytoband F1
Vascular remodeling in Fbln5tm1Eno/Fbln5tm1Eno mice after 28 days of ligation

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:86754
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA cassette containing lacZ and neo was inserted at the first start codon, located in exon 1a. Deleted sequence included the coding region of exon 1a, intron 1, and the 5' untranslated region of exon 1b. The downstream start codon, located in exon 1b, was left intact. Protein was undetected by Western blot analysis of skin fibroblasts and vascular smooth muscle cells obtained from homozygous mutant mice. (J:86754)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbln5 Mutation:  15 strains or lines available
Original:  J:86754 Yanagisawa H, et al., Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature. 2002 Jan 10;415(6868):168-71
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory