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Targeted Allele Detail
Symbol: Ghrtm1Arge
Name: growth hormone receptor; targeted mutation 1, Argiris Efstratiadis
MGI ID: MGI:2681515
Synonyms: Ghr-, Ghrex7-8
Gene: Ghr  Location: Chr15:3317760-3583492 bp, - strand  Genetic Position: Chr15, 1.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:66913
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced genomic sequences including exons 7, 8a and 8. Northern blot analysis demonstrated that no detectable transcript was expressed from this allele, and western blot analysis confirmed that no encoded protein was present in hepatic microsomal membrane extracts derived from homozygous mice. (J:66913)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ghr Mutation:  4 strains or lines available
Original:  J:66913 Lupu F, et al., Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev Biol. 2001 Jan 1;229(1):141-62
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory