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Targeted Allele Detail
Symbol: Igh-Jtm1(VDJ-KL25)Zbz
Name: immunoglobulin heavy chain, joining region; targeted mutation 1, Universitatsspital Zurich, Biologisches Zentrallaboratorium
MGI ID: MGI:2681436
Synonyms: TgH(KL25)
Gene: Igh-J  Location: unknown  Genetic Position: Chr12, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:86411
Parent Cell Line:  BL/6-III (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe endogenous DQ52 and all four heavy chain J elements were replaced by the rearranged heavy chain VDJ region of hybridoma KL25 5.8 (for a LCMV-neutralizing antibody) and a floxed neomycin resistance cassette. The neomycin cassette was removed in vivo by breeding to Cre deleter mice. This allele is expressed in more than 95% of all B cells. (J:86411)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh-J Mutation:  14 strains or lines available
Original:  J:86411 Hangartner L, et al., Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12883-8
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.19
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