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DpmlC57BL/6J
QTL Variant Detail
Summary
QTL variant: DpmlC57BL/6J
Name: dopamine loss; C57BL/6J
MGI ID: MGI:2681145
QTL: Dpml  Location: Chr15:51004694-76794493 bp  Genetic Position: Chr15, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers decreased MPTP-induced dopamine depletion in female animals compared to BALB/cJ.
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:85562

Genome scan was performed an a population of (C57BL/6J x BALB/cJ)F2 animals to detect loci associated with MPTP-induced dopamine depletion. MPTP is a neurotoxin that causes dopamine loss and Parkinson's disease symptoms in experimental animals. Parental strain C57BL/6J exhibits increased susceptibility to MPTP-induced dopamine depletion compared to BALB/cJ. Interestingly, female F2 animals exhibit a 31.6% mortality rate after MPTP administration whereas male F2 animals exhibit 0% mortality.

Dpml (dopamine loss), a female specific locus mapped to approximately 32.5 cM on mouse Chromosome 15 with LOD=4.8 between 21 cM (D15Mit100) and 44.1 cM (D15Mit68). BALB/cJ-derived alleles confer increased MPTP-induced dopamine depletion at Dpml. A candidate gene mapping to this region is Hsf1.

A suggestive locus mapped to 30 cM (D13Mit91) - 45 cM (D13Mit233) on mouse Chromosome 13. BALB/cJ-derived alleles confer increased MPTP-induced dopamine depletion at this locus.

An interacting locus pair reaching statisticalsignificance was also identified at 29 cM on mouse Chromosome 9 and 79.4 cM on mouse Chromosome 3. Interaction occurs between D9Mit14 and D3Mit147.

References
Original:  J:85562 Sedelis M, et al., Chromosomal loci influencing the susceptibility to the parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Neurosci. 2003 Sep 10;23(23):8247-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory