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Bmd3C3H/HeJ
QTL Variant Detail
Nomenclature
QTL variant: Bmd3C3H/HeJ
Name: bone mineral density 3; C3H/HeJ
MGI ID: MGI:2681001
QTL: Bmd3  Location: Chr13:20293442-20293650 bp  
QTL Note: genome coordinates based on the boundaries of the QTL region
Variant
origin
Strain of Specimen:  C3H/HeJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    The allele confers increased femoral BMD compared to C57BL/6J. (J:85226)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:58152

Bone mineral density (Bmd3) was measured as a quantitative trait (QTL) in a genome wide scan of 711 F2 mice in a genetic intercross involving C57BL/6J and CAST/Ei mice. C57BL/6J females express a low mineral bone density phenotype, alternatively CAST/Ei male express a high mineral bone density. Regression analysis was informative to show Bmd3 significantly associated with marker D13Mit16 within a defined QTL region bounded the centromere and D13Mit15. Due to the large size of the QTL region the authors did not suggest any candidate loci encoding for the Bone mineral density phenotype.

References
Original:  J:85226 Shultz KL, et al., Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral density. J Bone Miner Res. 2003 Feb;18(2):175-85
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory