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Cd38tm1Okam
Targeted Allele Detail
Nomenclature
Symbol: Cd38tm1Okam
Name: CD38 antigen; targeted mutation 1, Hiroshi Okamoto
MGI ID: MGI:2680868
Synonyms: CD38-
Gene: Cd38  Location: Chr5:43868809-43912374 bp, + strand  Genetic Position: Chr5, 23.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52933
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was flanked by single loxP sites and subsequently excised via cre mediated recombination, leaving a single loxP site in place of exon 1. Transcript was undetected in homozygous mutant mice by RT-PCR analysis of pancreatic RNA. Western blot analysis indicated an absence of protein. (J:52933)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd38 Mutation:  30 strains or lines available
References
Original:  J:52933 Kato I, et al., CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2+]i, and insulin secretion. J Biol Chem. 1999 Jan 22;274(4):1869-72
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory