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Targeted Allele Detail
Symbol: Rhotm1Jlem
Name: rhodopsin; targeted mutation 1, Janis Lem
MGI ID: MGI:2680822
Synonyms: mrho-, Opsin -, rhodopsin-
Gene: Rho  Location: Chr6:115931927-115938829 bp, + strand  Genetic Position: Chr6, 53.72 cM
Retinal morphology of Rhotm1Jlem/Rho+ and Rhotm1Jlem/Rhotm1Jlem mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:52281
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo cassette was inserted into the first coding exon of the endogenous gene, deleting 15 bp upstream of the translational start site and 111 codons. Transcript was undetected in homozygous mutant mice by Northern blot and RT-PCR analyses. Western blot analysis indicated an absence of protein in whole retinal homogenates. (J:52281)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rho Mutation:  9 strains or lines available
Original:  J:52281 Lem J, et al., Morphological, physiological, and biochemical changes in rhodopsin knockout mice. Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):736-41
All:  34 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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