About   Help   FAQ
Plcb3tm1Dwu
Targeted Allele Detail
Nomenclature
Symbol: Plcb3tm1Dwu
Name: phospholipase C, beta 3; targeted mutation 1, Dianqing Wu
MGI ID: MGI:2680661
Synonyms: PLC beta3-null
Gene: Plcb3  Location: Chr19:6931081-6951738 bp, - strand  Genetic Position: Chr19, 5.1 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57478
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced part of the exon encoding the X box. Western blot analysis demonstrated that no detectable protein was present in homogenates of dorsal root ganglia derived from homozygous mice. (J:57478)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plcb3 Mutation:  36 strains or lines available
References
Original:  J:57478 Xie W, et al., Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10385-90
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/30/2021
MGI 6.17
The Jackson Laboratory