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Targeted Allele Detail
Symbol: Kcnq1tm1Kpfe
Name: potassium voltage-gated channel, subfamily Q, member 1; targeted mutation 1, Karl Pfeifer
MGI ID: MGI:2680653
Synonyms: Kcnq1-
Gene: Kcnq1  Location: Chr7:142660614-142980787 bp, + strand  Genetic Position: Chr7, 88.12 cM
Histological analysis of inner ear structures of wild-type and Kcnq1tm1Kpfe/Kcnq1tm1Kpfe mice.

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:67873
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin resistance cassette into exon 2 disrupted the Kcnq1 gene. Northern blot analysis demonstrated that no detectable transcript was expressed in hearts of homozygous mice. (J:67873)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnq1 Mutation:  35 strains or lines available
Original:  J:67873 Casimiro MC, et al., Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange-Nielsen Syndrome. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2526-31
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory