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Targeted Allele Detail
Symbol: Cdk5r1tm1Ohsh
Name: cyclin-dependent kinase 5, regulatory subunit 1 (p35); targeted mutation 1, Toshio Ohshima
MGI ID: MGI:2680652
Synonyms: p35-, p35KO
Gene: Cdk5r1  Location: Chr11:80477046-80481179 bp, + strand  Genetic Position: Chr11, 47.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:67864
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into the gene, resulting in the deletion of amino acid residues 148 to the carboxy terminus in the encoded protein. Northern and western blot analysis confirmed the complete inactivation of the gene. (J:67864)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdk5r1 Mutation:  3 strains or lines available
Original:  J:67864 Ohshima T, et al., Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2764-9
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
The Jackson Laboratory