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Icmttm1Sgy
Targeted Allele Detail
Nomenclature
Symbol: Icmttm1Sgy
Name: isoprenylcysteine carboxyl methyltransferase; targeted mutation 1, Stephen G Young
MGI ID: MGI:2680650
Synonyms: Icmt -
Gene: Icmt  Location: Chr4:152297227-152307121 bp, + strand  Genetic Position: Chr4, 83.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67598
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 1 through homologous recombination. Activity of the encoded protein was shown to be abolished in homozygous ES cells. (J:62754)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Icmt Mutation:  7 strains or lines available
References
Original:  J:67598 Bergo MO, et al., Isoprenylcysteine carboxyl methyltransferase deficiency in mice. J Biol Chem. 2001 Feb 23;276(8):5841-5
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory