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Tgfbr1tm1.1Karl
Targeted Allele Detail
Nomenclature
Symbol: Tgfbr1tm1.1Karl
Name: transforming growth factor, beta receptor I; targeted mutation 1.1, Stefan Karlsson
MGI ID: MGI:2680164
Synonyms: Alk5loxP, Tgfbr1f
Gene: Tgfbr1  Location: Chr4:47353222-47414931 bp, + strand  Genetic Position: Chr4, 26.02 cM
Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl Ptentm1Hwu/Ptentm1Hwu Tg(KRT14-cre/ERT)20Efu/0 mice develop anal squamous cell carcinoma

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86262
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 3 was left flanked by single loxP sites after the removal of an upstream floxed neo cassette by the transient expression of cre recombinase in ES cells. (J:86262)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tgfbr1 Mutation:  22 strains or lines available
Notes
ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+) or GS (129S6/SvEvTac).
References
Original:  J:68770 Larsson J, et al., Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice. EMBO J. 2001 Apr 2;20(7):1663-73
All:  61 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory