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Dapp1tm1Mnz
Targeted Allele Detail
Nomenclature
Symbol: Dapp1tm1Mnz
Name: dual adaptor for phosphotyrosine and 3-phosphoinositides 1; targeted mutation 1, Michel C Nussenzweig
MGI ID: MGI:2680020
Synonyms: Bam32-
Gene: Dapp1  Location: Chr3:137931007-137981545 bp, - strand  Genetic Position: Chr3, 63.98 cM, cytoband H2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86182
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 1 was disrupted by the insertion of a neomycin selection cassette. Neither normal transcript nor aberrant splice products were detected by RT-PCR analysis. Protein was undetected by Western blot analysis of extracts of homozygous mutant splenic B cells. (J:86182)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dapp1 Mutation:  19 strains or lines available
References
Original:  J:86182 Han A, et al., Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival. Immunity. 2003 Oct;19(4):621-32
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory