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Stub1tm1Cpat
Targeted Allele Detail
Nomenclature
Symbol: Stub1tm1Cpat
Name: STIP1 homology and U-Box containing protein 1; targeted mutation 1, Cam Patterson
MGI ID: MGI:2680005
Synonyms: CHIP (-)
Gene: Stub1  Location: Chr17:25830634-25832919 bp, - strand  Genetic Position: Chr17, 12.93 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86213
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 through 3 were replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice by Western blot analysis. (J:86213)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Stub1 Mutation:  4 strains or lines available
References
Original:  J:86213 Dai Q, et al., CHIP activates HSF1 and confers protection against apoptosis and cellular stress. EMBO J. 2003 Oct 15;22(20):5446-58
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory