Pten^tm2.1Ppp
Targeted Allele Detail

Nomenclature

• Symbol: Pten^tm2.1Ppp
• Name: phosphatase and tensin homolog; targeted mutation 2.1, Pier Paolo Pandolfi
• MGI ID: MGI:2679886
• Synonyms: Pten^fl, Pten^L, Pten^lox4-5, Pten^loxP, Pten^lx
• Gene: Pten Location: Chr19:32757497-32826160 bp, + strand Genetic Position: Chr19, 28.14 cM

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86212
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 4 and 5 were left flanked by single loxP sites after the floxed neo cassette was removed from intron 3 of Pten^tm2Ppp via in vivo cre mediated recombination.

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 41 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Astrocytoma J:99385.

Phenotypic Similarity to Human Syndrome: Sporatic Malignant Peripheral Nerve Sheath Tumor J:195067 in Pten^tm2.1Ppp/ Pten^tm2.1Ppp Tg(Dhh-cre)1Mejr/0 Tg(Cnp-EGFR)10Nrat/0 mice.

Phenotypic Similarity to Human Syndrome: Thyroid Follicular Carcinoma J:165293 in mice homozygous for this allele and hemizygous for Tg(TPO-cre)1Shk.

Phenotypic Similarity to Human Syndrome: Thyroid Cancer J:231492 in conditional mice homozygous for Hras^tm1Jaf and homozygous for either Nf2^tm2Gth, Trp53^tm1Brn or Pten^tm2.1Ppp.

References

• Original: J:86212 Trotman LC, et al., Pten Dose Dictates Cancer Progression in the Prostate. PLoS Biol. 2003 Dec;1(3):385-96
• All: 63 reference(s)