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Ptentm2.1Ppp
Targeted Allele Detail
Nomenclature
Symbol: Ptentm2.1Ppp
Name: phosphatase and tensin homolog; targeted mutation 2.1, Pier Paolo Pandolfi
MGI ID: MGI:2679886
Synonyms: Ptenf, Ptenfl, PtenL, Ptenlox4-5, PtenloxP, Ptenlx
Gene: Pten  Location: Chr19:32757497-32826160 bp, + strand  Genetic Position: Chr19, 28.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86212
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 4 and 5 were left flanked by single loxP sites after the floxed neo cassette was removed from intron 3 of Ptentm2Ppp via in vivo cre mediated recombination.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  36 strains or lines available
Notes

Phenotypic Similarity to Human Syndrome: Follicular Thyroid Carcinoma J:236513 (DOID:3962) in double Kras and Pten conditional (Tg(Tpo-cre)1Shk) mutants.

Phenotypic Similarity to Human Syndrome: Anaplastic Thyroid Cancer J:209788 in double Trp53 and Pten homozygous conditional (Tg(TPO-cre)1Shk) mice.

References
Original:  J:86212 Trotman LC, et al., Pten Dose Dictates Cancer Progression in the Prostate. PLoS Biol. 2003 Dec;1(3):385-96
All:  98 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory