Pten^tm2.1Ppp
Targeted Allele Detail

Nomenclature

Symbol:	Pten^tm2.1Ppp
Name:	phosphatase and tensin homolog; targeted mutation 2.1, Pier Paolo Pandolfi
MGI ID:	MGI:2679886
Synonyms:	Pten^fl, Pten^L, Pten^lox4-5, Pten^loxP, Pten^lx
Gene:	Pten  Location: Chr19:32757497-32826160 bp, + strand  Genetic Position: Chr19, 28.14 cM

Mutation origin

Germline Transmission:	Earliest citation of germline transmission: J:86212
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2^+ Tyr^+ Kitl^+

Mutation description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: Exons 4 and 5 were left flanked by single loxP sites after the floxed neo cassette was removed from intron 3 of Pten^tm2Ppp via in vivo cre mediated recombination.

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:	36 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Astrocytoma (J:99385)

Phenotypic Similarity to Human Syndrome: Sporatic Malignant Peripheral Nerve Sheath Tumor in Pten^tm2.1Ppp/ Pten^tm2.1Ppp Tg(Dhh-cre)1Mejr/0 Tg(Cnp-EGFR)10Nrat/0 mice (J:195067).

References

Original:	J:86212 Trotman LC, et al., Pten Dose Dictates Cancer Progression in the Prostate. PLoS Biol. 2003 Dec;1(3):385-96
All:	52 reference(s)