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Targeted Allele Detail
Symbol: Ptentm2.1Ppp
Name: phosphatase and tensin homolog; targeted mutation 2.1, Pier Paolo Pandolfi
MGI ID: MGI:2679886
Synonyms: Ptenfl, PtenL, Ptenlox4-5, PtenloxP, Ptenlx
Gene: Pten  Location: Chr19:32757497-32826160 bp, + strand  Genetic Position: Chr19, 28.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:86212
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExons 4 and 5 were left flanked by single loxP sites after the floxed neo cassette was removed from intron 3 of Ptentm2Ppp via in vivo cre mediated recombination.
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  43 strains or lines available
Phenotypic Similarity to Human Syndrome: Astrocytoma J:99385.

Phenotypic Similarity to Human Syndrome: Sporatic Malignant Peripheral Nerve Sheath Tumor J:195067 in Ptentm2.1Ppp/ Ptentm2.1Ppp Tg(Dhh-cre)1Mejr/0 Tg(Cnp-EGFR)10Nrat/0 mice.

Phenotypic Similarity to Human Syndrome: Thyroid Follicular Carcinoma J:165293 in mice homozygous for this allele and hemizygous for Tg(TPO-cre)1Shk.

Phenotypic Similarity to Human Syndrome: Thyroid Cancer J:231492 in conditional mice homozygous for Hrastm1Jaf and homozygous for either Nf2tm2Gth, Trp53tm1Brn or Ptentm2.1Ppp.

Original:  J:86212 Trotman LC, et al., Pten Dose Dictates Cancer Progression in the Prostate. PLoS Biol. 2003 Dec;1(3):385-96
All:  71 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.09
The Jackson Laboratory