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Kat6bGt(pKC199)1Pgr
Gene trapped Allele Detail
Nomenclature
Symbol: Kat6bGt(pKC199)1Pgr
Name: K(lysine) acetyltransferase 6B; gene trap 1, Peter Gruss
MGI ID: MGI:2679726
Synonyms: qkfgt, querkopfgt
Gene: Kat6b  Location: Chr14:21481434-21672478 bp, + strand  Genetic Position: Chr14, 11.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62161
Parent Cell Line:  MPI-II (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector
 
Mutation detailsThe insertion of a gene trap vector into a 5' untranslated exon resulted in a hypomorphic allele from which normal coding mRNA is produced at a level approximately 10% that of the wild-type. The insertion site corresponds with base 76 of the cDNA. (J:62161)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kat6b Mutation:  43 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Noonan syndrome in homozygous mice (J:178264)

References
Original:  J:62161 Thomas T, et al., Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development. Development. 2000 Jun;127(12):2537-48
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory