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Targeted Allele Detail
Symbol: Lamc2tm1Uit
Name: laminin, gamma 2; targeted mutation 1, Jouni Uitto
MGI ID: MGI:2679597
Synonyms: Lamc2-
Gene: Lamc2  Location: Chr1:153122756-153186447 bp, - strand  Genetic Position: Chr1, 65.26 cM, cytoband H1
Germline Transmission:  Earliest citation of germline transmission: J:85981
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neomycin resistance gene was inserted in intron 8 and another loxP site was placed in intron 7. Also, frt sites were inserted on either side of exon 9. Transient cre expression in the ES cells removed exon 8 which caused a frame shift and a premature termination codon in exon 9. RT-PCR indicated mRNA of 510bp rather than 623bp. There was also a minor smaller transcript of 291bp. No protein product could be seen immunologically in skin biopsies of homozygous mice. (J:85981)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lamc2 Mutation:  15 strains or lines available
Original:  J:85981 Meng X, et al., Targeted inactivation of murine laminin gamma2-chain gene recapitulates human junctional epidermolysis bullosa. J Invest Dermatol. 2003 Oct;121(4):720-31
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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