Smad5^tm1Huy
Targeted Allele Detail

Summary

• Symbol: Smad5^tm1Huy
• Name: SMAD family member 5; targeted mutation 1, Danny Huylebroeck
• MGI ID: MGI:2679441
• Synonyms: Smad5^flE2, Smad5^flox, Smad5^fx, Smad5^fx(exon2)
• Gene: Smad5 Location: Chr13:56850823-56890190 bp, + strand Genetic Position: Chr13, 30.12 cM
• Alliance: Smad5^tm1Huy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86157
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by single loxP sites. Exon 2 contains the translational start codon and approximately one-third of the protein coding sequence. (J:86157)

Disease models

Expression

In Mice Carrying this Mutation:	86 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smad5^tm1Huy

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad5 Mutation: 23 strains or lines available

References

• Original: J:86157 Umans L, et al., Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse. Genesis. 2003 Sep;37(1):5-11
• All: 33 reference(s)