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Drd2tm1(IL2RA)Koba
Targeted Allele Detail
Nomenclature
Symbol: Drd2tm1(IL2RA)Koba
Name: dopamine receptor D2; targeted mutation 1, Kazuto Kobayashi
MGI ID: MGI:2679435
Gene: Drd2  Location: Chr9:49340627-49408177 bp, + strand  Genetic Position: Chr9, 26.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85929
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe human IL2RA gene was inserted into exon 2 of the endogenous locus. Thet targeting construct included a polyadenylation signal and neo gene immediately downstream of IL2RA. Treatment of mutant mice with a recombinant immunotoxin consisting of the variable regions of the anti-IL2RA monoclonal antibody fused to a bacterial exotoxin results in the specific ablation of cells expressing IL2RA via the Drd2 promoter. (J:85929)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd2 Mutation:  58 strains or lines available
References
Original:  J:85929 Sano H, et al., Conditional ablation of striatal neuronal types containing dopamine D2 receptor disturbs coordination of basal ganglia function. J Neurosci. 2003 Oct 8;23(27):9078-88
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory