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Limk1tm1Zpj
Targeted Allele Detail
Nomenclature
Symbol: Limk1tm1Zpj
Name: LIM-domain containing, protein kinase; targeted mutation 1, Zhengping Jia
MGI ID: MGI:2679321
Synonyms: LIMK-1-
Gene: Limk1  Location: Chr5:134656039-134688598 bp, - strand  Genetic Position: Chr5, 74.73 cM, cytoband G2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86283
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe exons containing the second LIM domain and the PDZ domain were replaced with a PGK-neo cassette. In resulting homozygotes, no mRNA expression or protein product was detected. (J:86283)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Limk1 Mutation:  18 strains or lines available
References
Original:  J:86283 Meng Y, et al., Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron. 2002 Jul 3;35(1):121-33
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory