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Prkcatm1Far
Targeted Allele Detail
Nomenclature
Symbol: Prkcatm1Far
Name: protein kinase C, alpha; targeted mutation 1, Bob Farese
MGI ID: MGI:2679305
Synonyms: PKCalpha-
Gene: Prkca  Location: Chr11:107933387-108343928 bp, - strand  Genetic Position: Chr11, 70.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85923
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with a neomycin selection cassette via homolgous recombination. Normal transcript was undetected by RT-PCR analysis RNA obtained from the brain tissue of homozygous mutant mice. (J:85923)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkca Mutation:  21 strains or lines available
References
Original:  J:85923 Leitges M, et al., Knockout of PKC alpha enhances insulin signaling through PI3K. Mol Endocrinol. 2002 Apr;16(4):847-58
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory