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Fcgr1tm1Hoga
Targeted Allele Detail
Nomenclature
Symbol: Fcgr1tm1Hoga
Name: Fc receptor, IgG, high affinity I; targeted mutation 1, P Mark Hogarth
MGI ID: MGI:2679238
Synonyms: FcgammaRI-, FcRI-
Gene: Fcgr1  Location: Chr3:96282909-96293969 bp, - strand  Genetic Position: Chr3, 41.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86280
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 400 bp fragment was deleted from the 5' portion of the gene. This deleted sequence included the promoter and the transcription and translation start sites. In addition a neo cassette was inserted into the second leader exon, disrupting the leader sequence and generating a premature stop codon immediately downstream of exon 2. Transcript was undetected by Northern blot analysis of homozygous bone marrow macrophages (BMM) even after stimulation with interferon gamma. Surface protein was undetected via ligand or antibody binding. (J:86281)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fcgr1 Mutation:  9 strains or lines available
References
Original:  J:86280 Gavin AL, et al., Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity. J Immunol. 1998 Jan 1;160(1):20-3
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory