Ptprz1^tm1Mno
Targeted Allele Detail

Summary

• Symbol: Ptprz1^tm1Mno
• Name: protein tyrosine phosphatase receptor type Z, polypeptide 1; targeted mutation 1, Masaharu Noda
• MGI ID: MGI:2678757
• Synonyms: PTPZeta^-
• Gene: Ptprz1 Location: Chr6:22875501-23052915 bp, + strand Genetic Position: Chr6, 9.92 cM
• Alliance: Ptprz1^tm1Mno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85827
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing lacZ and neo was inserted just downstream of the start codon in exon 1, such that the first 4 codons, which encode the signal peptide, were left intact. Protein was undetected in brain tissue of homozygous mutant mice by Western blot analysis using an antibody targeted against the endogenous extracellular domain. LacZ expression was verified by X-gal staining. (J:85827)

Expression

In Mice Carrying this Mutation:

13 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprz1 Mutation: 139 strains or lines available

References

• Original: J:85827 Shintani T, et al., Neurons as well as astrocytes express proteoglycan-type protein tyrosine phosphatase zeta/RPTPbeta: analysis of mice in which the PTPzeta/RPTPbeta gene was replaced with the LacZ gene. Neurosci Lett. 1998 May 15;247(2-3):135-8
• All: 15 reference(s)