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Gene trapped Allele Detail
Symbol: Pkp4Gt(pT1Betageo)1Ruiz
Name: plakophilin 4; gene trap 1, Patricia Ruiz
MGI ID: MGI:2678397
Gene: Pkp4  Location: Chr2:59160850-59355205 bp, + strand  Genetic Position: Chr2, 33.52 cM, cytoband C3
Mutant Cell Line:  W024F10
Germline Transmission:  Earliest citation of germline transmission: J:85162
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pT1betageo
Mutation detailsThe endogenous locus was disrupted by the insertion of a gene trap vector containing a splice acceptor site followed by Beta-geo and a polyadenylation signal. (J:85162)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pkp4 Mutation:  103 strains or lines available
Information submitted to the NCBI Genome Survey Sequences Database (dbGSS) by the German Genetrap Consortium (GGTC) for gene trap cell line W024F10 gives R1 as the ES cell line used to create this allele. The original publication reporting large scale production of gene trap clones using four gene trap vectors says that ES cell-derived chimeras were produced using three ES cell lines (E14.1 (129P2/OlaHsd), R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+), TBV2 (129S2/SvPas)). GGTC records currently say that E14 ES cells were used to generate this allele. Chimeric mice were subsquently bred to C57BL/6 females.
Original:  J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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