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Mnttm1.1Phu
Targeted Allele Detail
Nomenclature
Symbol: Mnttm1.1Phu
Name: max binding protein; targeted mutation 1.1, Peter J Hurlin
MGI ID: MGI:2678322
Synonyms: Mnt-
Gene: Mnt  Location: Chr11:74830920-74845725 bp, + strand  Genetic Position: Chr11, 45.76 cM, cytoband B-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85481
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsMice heterozygous for Mnttm1Phu were crossed with transgenic mice carryingTgN(EIIa-cre)C5379Lmgd. In mice carrying both the transgene and Mnttm1Phu, cre excision removed exons 4 to 6 as well as the Hygro selection cassette. The predicted protein product would thus lack the C-terminal amino acids from residue 235 to 591. No mRNA transcripts were identified by RT-PCR in embryos homozygous for this disruption. (J:85481)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mnt Mutation:  19 strains or lines available
References
Original:  J:85481 Hurlin PJ, et al., Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J. 2003 Sep 15;22(18):4584-96
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory