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Tmevd5C57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: Tmevd5C57BL/6J
Name: Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5; C57BL/6J
MGI ID: MGI:2678008
QTL: Tmevd5  Location: Chr11:89835299-89835463 bp  Genetic Position: Chr11, cM position of peak correlated region/allele: 54.6 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased demyelinating disease severity compared to 129. (J:69154)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:69154

Two F2 intercrosses [(C57BL/6J Ifng-/- x 129/Sv)F2 and (C57BL/6J x 129/Sv Ifngr-/-)F2] were used to map a locus, Tmevd5 (LOD = 4.8 with D11Mit179), on mouse Chromosome 11 (33.4 cM - 47.7 cM) influencing the severity of demyelinating disease caused by Theiler's virus. C57BL/6J Ifng-/- is less susceptible to viral infection and disease-related symptoms than 129/Sv Ifngr-/-. 45 days post-inoculation with Theiler's virus, animals from both F2 crosses showed a higher viral load than animals from either parental strain (C57BL/6J Ifng-/- or 129/Sv Ifngr-/-). Tmevd5 was identified in the (C57BL/6J x 129/Sv Ifngr-/-)F2 cross using both male and female mice. Further analysis revealed a suggestive locus influencing disease severity in female mice on Chromosome 19 linked to D19Mit65 (LOD = 2.9), D19Mit119 (LOD = 2.9), and D19Mit83 (LOD = 2.6).

References
Original:  J:69154 Aubagnac S, et al., Viral load and a locus on chromosome 11 affect the late clinical disease caused by Theiler's virus. J Virol. 1999 Oct;73(10):7965-71
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory