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Puratm1Kkh
Targeted Allele Detail
Summary
Symbol: Puratm1Kkh
Name: purine rich element binding protein A; targeted mutation 1, Kamel Khalili
MGI ID: MGI:2677937
Synonyms: PURA-
Gene: Pura  Location: Chr18:36414150-36425588 bp, + strand  Genetic Position: Chr18, 19.46 cM, cytoband B3
Alliance: Puratm1Kkh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85759
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was disrupted by a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by Western blot analysis of homozygous mutant brain tissue. (J:85759)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pura Mutation:  26 strains or lines available
References
Original:  J:85759 Khalili K, et al., Puralpha is essential for postnatal brain development and developmentally coupled cellular proliferation as revealed by genetic inactivation in the mouse. Mol Cell Biol. 2003 Oct;23(19):6857-75
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory