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Pasktm1Weng
Targeted Allele Detail
Nomenclature
Symbol: Pasktm1Weng
Name: PAS domain containing serine/threonine kinase; targeted mutation 1, Roland H Wenger
MGI ID: MGI:2677908
Synonyms: PASK-, Paskin-
Gene: Pask  Location: Chr1:93309437-93343522 bp, - strand  Genetic Position: Chr1, 47.24 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85762
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 10 through 14 were replace with a cassette containing a splice acceptor site and IRES-beta-geo. Norhtern blot analysis of various tissues confirmed the absence of endogenous transcript and identified mutant transcript containing the beta-geo squenence. (J:85762)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pask Mutation:  39 strains or lines available
References
Original:  J:85762 Katschinski DM, et al., Targeted disruption of the mouse PAS domain serine/threonine kinase PASKIN. Mol Cell Biol. 2003 Oct;23(19):6780-9
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory