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Targeted Allele Detail
Symbol: Myl1tm1Nros
Name: myosin, light polypeptide 1; targeted mutation 1, Nadia Rosenthal
MGI ID: MGI:2677883
Synonyms: MLCE-
Gene: Myl1  Location: Chr1:66924295-66945404 bp, - strand  Genetic Position: Chr1, 33.71 cM
Germline Transmission:  Earliest citation of germline transmission: J:77516
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Other
Mutation detailsThe MLC downstream enhancer was deleted via two steps of homologous recombination. Ultimately, the allele lacked the MLC downstream enchancer and surrounding sequence (a 1.5 kb genomic fragment) and contained no exogenous sequence. (J:77516)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 9 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myl1 Mutation:  5 strains or lines available
Original:  J:77516 Jiang P, et al., Targeted deletion of the MLC1f/3f downstream enhancer results in precocious MLC expression and mesoderm ablation. Dev Biol. 2002 Mar 15;243(2):281-93
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory