Sftpa1^tm1Haw
Targeted Allele Detail

Summary

• Symbol: Sftpa1^tm1Haw
• Name: surfactant associated protein A1; targeted mutation 1, Samuel Hawgood
• MGI ID: MGI:2677859
• Synonyms: SP-A -
• Gene: Sftpa1 Location: Chr14:40853745-40858330 bp, + strand Genetic Position: Chr14, 22.36 cM
• Alliance: Sftpa1^tm1Haw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86024
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129/Sv)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2, 3, and 4 including the translation start site as well as short segments of flanking intronic sequence were replaced with a PGK neomycin cassette. Resulting mice lacked mRNA transcripts and their protein product. (J:86023, J:86024)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Sftpa1 Mutation: 20 strains or lines available

References

• Original: J:86024 Li G, et al., Surfactant protein-A--deficient mice display an exaggerated early inflammatory response to a beta-resistant strain of influenza A virus. Am J Respir Cell Mol Biol. 2002 Mar;26(3):277-82
• All: 27 reference(s)