Tsn^{Gt(OST63223)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Tsn^{Gt(OST63223)Lex}
• Name: translin; gene trap OST63223, Lexicon Genetics
• MGI ID: MGI:2677496
• Synonyms: Tsn^{Gt(Betageo)1Nbh}
• Gene: Tsn Location: Chr1:118226244-118239463 bp, - strand Genetic Position: Chr1, 52.14 cM
• Alliance: Tsn^{Gt(OST63223)Lex} page

Mutation origin

• Mutant Cell Line: OST63223
• Germline Transmission: Earliest citation of germline transmission: J:85466
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector inserted into intron 4 of the endogenous gene. The vector contained a 5' long terminal repeate (LTR), a splice acceptor, beta-geo, a Bruton tyrosine kinase gene, and a 3' LTR. Neither transcript nor protein was detected in various homozygous mutant tissues. (J:85466)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST63223	CG511102 ; (MGI Seq Detail)	3' RACE	Chr1:118228569-118233034 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  12 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tsn Mutation: 26 strains or lines available

References

• Original: J:85466 Chennathukuzhi V, et al., Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes. Mol Cell Biol. 2003 Sep;23(18):6419-34
• All: 6 reference(s)