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Lipetm1Land
Targeted Allele Detail
Summary
Symbol: Lipetm1Land
Name: lipase, hormone sensitive; targeted mutation 1, Dominique Langin
MGI ID: MGI:2677463
Synonyms: HSL
Gene: Lipe  Location: Chr7:25078952-25097911 bp, - strand  Genetic Position: Chr7, 13.78 cM, cytoband A3
Alliance: Lipetm1Land page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85895
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe catalytic domain was disrupted by the insertion of GFP and neo into exon 5. Protein was undetected in homozygous mutant mice by Western blot analysis of intestinal mucosa extracts. Cholesterol esterase activity was completely abolished in the intestinal mucosa of homozygous mutant mice. (J:85895)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lipe Mutation:  36 strains or lines available
References
Original:  J:85895 Grober J, et al., Hormone-sensitive lipase is a cholesterol esterase of the intestinal mucosa. J Biol Chem. 2003 Feb 21;278(8):6510-5
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory