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Targeted Allele Detail
Symbol: Pdpk1tm1Mlw
Name: 3-phosphoinositide dependent protein kinase 1; targeted mutation 1, Margaret A Lawlor
MGI ID: MGI:2677460
Synonyms: PDK1FL, pdk1hm, PDKfl, pdkhm
Gene: Pdpk1  Location: Chr17:24073680-24150924 bp, - strand  Genetic Position: Chr17, 12.23 cM, cytoband A3.3
Germline Transmission:  Earliest citation of germline transmission: J:85894
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neomycin cassette was inserted in intron 2 while an additional loxP site was inserted in intron 4. Presence of the neomycin gene in intron 2 results in reduced PDK1 levels. (J:85894)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdpk1 Mutation:  124 strains or lines available
Original:  J:85894 Lawlor MA, et al., Essential role of PDK1 in regulating cell size and development in mice. EMBO J. 2002 Jul 15;21(14):3728-38
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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