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Targeted Allele Detail
Symbol: Sirt1tm2.1Fwa
Name: sirtuin 1; targeted mutation 2.1, Frederick W Alt
MGI ID: MGI:2677369
Synonyms: SIRT1-, SIRT1delta, SIRT1null, SIRT null
Gene: Sirt1  Location: Chr10:63319005-63339035 bp, - strand  Genetic Position: Chr10, 32.57 cM
Germline Transmission:  Earliest citation of germline transmission: J:85542
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA single loxP site remained in place of exons 5, 6, and 7 after the floxed neo cassette inserted by homologous recombination was excised via in vitro cre-mediated recombination. Protein was undetected in homozygous mutant MEFs by Western blot analysis using an antibody specific for the N-terminal. (J:85542)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sirt1 Mutation:  51 strains or lines available
Original:  J:85542 Cheng HL, et al., Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10794-9
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory