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Ephb1tm1Cmn
Targeted Allele Detail
Nomenclature
Symbol: Ephb1tm1Cmn
Name: Eph receptor B1; targeted mutation 1, Carol A Mason
MGI ID: MGI:2677305
Synonyms: EphB1-, EphB1KO
Gene: Ephb1  Location: Chr9:101922128-102354693 bp, - strand  Genetic Position: Chr9, 54.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85573
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 has been replaced by a neomycin resistance gene which causes a frame shift in addition to the exon loss. Western blot analysis confirmed the absence of protein product. (J:85573)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ephb1 Mutation:  3 strains or lines available
References
Original:  J:85573 Williams SE, et al., Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm. Neuron. 2003 Sep 11;39(6):919-35
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory