Igf2^tm1Rob
Targeted Allele Detail

Summary

• Symbol: Igf2^tm1Rob
• Name: insulin-like growth factor 2; targeted mutation 1, Elizabeth J Robertson
• MGI ID: MGI:2677156
• Synonyms: Igf2^-, IGF2(-), Igf-2(p-), Igf2^tm1Rob-pat, Igf-II(-)
• Gene: Igf2 Location: Chr7:142204503-142220553 bp, - strand Genetic Position: Chr7, 87.99 cM
• Alliance: Igf2^tm1Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:10453
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequences encoding part of the first coding exon were replaced with a neomycin resistance gene cassette. (J:10453)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	24 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Igf2^tm1Rob

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igf2 Mutation: 25 strains or lines available

Notes

This gene is maternally imprinted and only expressed when paternally inherited. Inheritance of the maternal allele in the heterozygous state is equivalent to wild-type homozygotes where as inheritance of the paternal allele in the heterogyzous state is equivalent to knock-out homozygotes.

References

• Original: J:10453 DeChiara TM, et al., A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature. 1990 May 3;345(6270):78-80
• All: 59 reference(s)