About   Help   FAQ
Igf2tm1Rob
Targeted Allele Detail
Nomenclature
Symbol: Igf2tm1Rob
Name: insulin-like growth factor 2; targeted mutation 1, Elizabeth J Robertson
MGI ID: MGI:2677156
Synonyms: Igf2-, IGF2(-), Igf-2(p-), Igf2tm1Rob-pat, Igf-II(-)
Gene: Igf2  Location: Chr7:142650766-142666816 bp, - strand  Genetic Position: Chr7, 87.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:10453
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of sequences encoding part of the first coding exon with a neomycin cassette (J:10453)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf2 Mutation:  5 strains or lines available
Notes
This gene is maternally imprinted and only expressed when paternally inherited. Inheritance of the maternal allele in the heterozygous state is equivalent to wild-type homozygotes where as inheritance of the paternal allele in the heterogyzous state is equivalent to knock-out homozygotes.

References
Original:  J:10453 DeChiara TM, et al., A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature. 1990 May 3;345(6270):78-80
All:  46 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory