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Targeted Allele Detail
Symbol: Igf2tm1Rob
Name: insulin-like growth factor 2; targeted mutation 1, Elizabeth J Robertson
MGI ID: MGI:2677156
Synonyms: Igf2-, IGF2(-), Igf-2(p-), Igf2tm1Rob-pat, Igf-II(-)
Gene: Igf2  Location: Chr7:142650766-142666816 bp, - strand  Genetic Position: Chr7, 87.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:10453
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of sequences encoding part of the first coding exon with a neomycin cassette (J:10453)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 21 assay results
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf2 Mutation:  10 strains or lines available
This gene is maternally imprinted and only expressed when paternally inherited. Inheritance of the maternal allele in the heterozygous state is equivalent to wild-type homozygotes where as inheritance of the paternal allele in the heterogyzous state is equivalent to knock-out homozygotes.
Original:  J:10453 DeChiara TM, et al., A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature. 1990 May 3;345(6270):78-80
All:  50 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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