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Targeted Allele Detail
Symbol: Igf2tm1Wrk
Name: insulin-like growth factor 2; targeted mutation 1, Wolf Reik
MGI ID: MGI:2677155
Synonyms: DeltaDMR1-U2, Igf2P0-, Igf2tm1Wrk-pat, P0
Gene: Igf2  Location: Chr7:142650766-142666816 bp, - strand  Genetic Position: Chr7, 87.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:65001
Parent Cell Line:  CGR8 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsSequence encompassing the second placenta-specific exon (U2) and the first differentially methylated region (DMR1), located 3 kb upstream of the first fetal promoter (P1), was replaced by a single loxP site following cre-mediated recombination. In contrast to the wild-type allele which is silenced soon after birth, both maternally and paternally transmitted alleles were continually transcribed postnatally. In addition to the loss of imprinting, the deletion resulted in the ablation of placenta-specific transcript. Transcript was undetected by in situ hybridization of placentae from heterozygous mice carrying a paternally transcribed mutant allele. (J:65001)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf2 Mutation:  10 strains or lines available
Original:  J:65001 Constancia M, et al., Deletion of a silencer element in igf2 results in loss of imprinting independent of H19. Nat Genet. 2000 Oct;26(2):203-6
All:  11 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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