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Igf2tm1Wrk
Targeted Allele Detail
Nomenclature
Symbol: Igf2tm1Wrk
Name: insulin-like growth factor 2; targeted mutation 1, Wolf Reik
MGI ID: MGI:2677155
Synonyms: DeltaDMR1-U2, Igf2P0-, Igf2tm1Wrk-pat, P0
Gene: Igf2  Location: Chr7:142650766-142666816 bp, - strand  Genetic Position: Chr7, 87.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65001
Parent Cell Line:  CGR8 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsSequence encompassing the second placenta-specific exon (U2) and the first differentially methylated region (DMR1), located 3 kb upstream of the first fetal promoter (P1), was replaced by a single loxP site following cre-mediated recombination. In contrast to the wild-type allele which is silenced soon after birth, both maternally and paternally transmitted alleles were continually transcribed postnatally. In addition to the loss of imprinting, the deletion resulted in the ablation of placenta-specific transcript. Transcript was undetected by in situ hybridization of placentae from heterozygous mice carrying a paternally transcribed mutant allele. (J:65001)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf2 Mutation:  9 strains or lines available
References
Original:  J:65001 Constancia M, et al., Deletion of a silencer element in igf2 results in loss of imprinting independent of H19. Nat Genet. 2000 Oct;26(2):203-6
All:  11 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory